CHIR99021 （CT99021） HCl （2mg）

簡要描述：主要產品線：生化試劑（60萬種）、抗體（10萬種）、細胞因子、二抗、ECL發光液、蛋白marker、激動劑、抑制劑、凋亡試劑盒、BSA、動植物提取劑、蛋白酶K....

產品型號：abs818358a
廠商性質：生產廠家
更新時間：2025-06-12
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生化試劑

其它生化試劑植物提取物碳水化合物生物緩沖劑氨基酸及衍生物熒光探針與染料表面活性劑酶&輔酶&酶底物蛋白質組學動植物激素小分子化合物生化檢測試劑盒逆行示蹤劑抗生素核苷&核苷酸多肽

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詳細介紹

品牌	absin	供貨周期	兩周

概述
描述	CHIR-99021 monohydrochloride is a GSK-3α/β inhibitor with IC₅₀ of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.

性能
保存方法	-20°C
純度	≥98%
分子量	501.8
化學式	C??H??Cl?N?
分子結構式
溶解性	DMSO：93 mg/mL (185.33 mM) Ethanol：2 mg/mL (3.98 mM)
CAS號	1797989-42-4
外觀	powder

參考文獻
[1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5). [3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3) [4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. [5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.

參考文獻

[1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

[2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5).

[3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3)

[4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.

[5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24.

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CHIR99021 （CT99021） HCl （2mg）

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